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ABOUT  |  SERVICES  |  PRODUCTS  |  CAREERS 

OUR SERVICES
 
PROCESS DEVELOPMENT

Snapdragon Chemistry provides process improvement and scale-up services. With our world-class consulting capability, we can suggest process improvement ideas that leverage technology to:

  • Reduce the number of transformations required to synthesize a given molecule. 

  • Improve the efficiency of the transformations.  

Moreover, our laboratory services support the implementation of these ideas to prepare scaled quantities of your target product. Snapdragon Chemistry will also work with your in-house team to establish process-scale reactors to ensure seamless technology transfer.

 

Some of the reactors we use to develop processes for our clients include:

  • PLUG FLOW

  • PACKED BED

  • CSTR

  • PHOTOREACTOR

  • ELECTROCHEM

 

See more detailed reactor information. >>

 

 We leverage our advanced capabilities in autonomous process development to deliver robust and scalable chemistry solutions. Snapdragon Chemistry can leverage our expertise in reactor platforms to deliver chemistry solutions for your toughest problems.

REACTOR DESIGN & BUILD

After establishing the process, Snapdragon chemists and engineers can work together to build a self-contained reactor "skid" to allow the process to be performed anywhere.  Our process engineering team develops a 3D CAD model of the skid prior to ordering and assembling custom components for the system, allowing for "right first time" designs as well as clear communication with the client and the production facility. Customers use our skids for medicinal chemistry scale-up, process development, and production in GMP environments (kilo lab and plant).

Our R&D skids are designed to give our clients the power to use Snapdragon process development tools in their own labs. These systems can be based on platform technologies such as hydrogenation, high temperature/pressure, and photochemistry. They can be customized to meet the client's requirements, and include Snapdragon control software to allow for these complex systems to be managed easily.

Our GMP production skids use industry-standard automation technologies including PLC-based control panels and a PC-based SCADA system. The control panels can be constructed to comply with a range of electrical safety requirements as needed, including UL and CE, and they can be rated for use in hazardous locations (explosion-proof/ATEX). The SCADA system provides a user interface as well as a data historian compliant with GMP electronic records requirements (21 CFR Part 11). These control systems can be used to operate the equipment through a single interface, and they can also accommodate automation functions such as start-up, shut-down, emergency stop, and clean-in-place. Our automation systems can integrate into any plant-wide control system.

 
PORTFOLIO OPTIMIZATION

Snapdragon Chemistry can help you develop and optimize chemical reactions. Depending upon your stage of development, we provide consulting services regarding:

  • FEASIBILITY OF APPLYING NOVEL TECHNOLOGY TO A REACTION

  • REACTOR DESIGN AND SET-UP

  • SPECIFIC CONDITIONS AND PARAMETERS TO OPTIMIZE A REACTION

  • PORTFOLIO OPTIMIZATION

 

Based on your needs, our talented chemists and engineers provide holistic chemistry services to rapidly develop and optimize reactions so that you can focus on other priorities. We understand the importance of seamless technology transfer either within your own facilities or through our GMP manufacturing partners. We are happy to work with you to determine a customized plan that best suits your needs.

While we are agnostic as to the process development approach utilized, we have unique expertise in completing multiple synthetic steps in one continuous flow process across a broad set of reactions and conditions. By employing integrated multi-step processes, customers tap into some of the greatest benefits of this novel chemical technology. Our leadership has led many of the major developments in the flow chemistry field, and we employ chemists that have had hands-on experience in developing these continuous processes.

OPTIMIZE EARLY

Continuous flow chemistry is typically used as a last resort to address challenges that arise in conventional batch methodology. As a result, there are often missed opportunities to apply continuous flow chemistry to enhance product development and gain the greatest advantages of flow technology. We offer a detailed analysis of your portfolios, reviewing reactions and processes across a set of molecules and proactively identifying key opportunities to use innovative chemistry to improve productivity.

WORK WITH THE EXPERTS

We have unparalleled expertise in utilizing flow technology to transform synthetic routes (e.g., reducing the number of synthetic steps, improving conversion, and decreasing residence time) and substantially increasing their efficiency. Our broad experience in translating reactions into flow enables us to take a unique look at your portfolio to identify these opportunities and help you achieve a step-change in productivity.

 
GMP MANUFACTURING

Snapdragon Chemistry offers state-of-the-art process development, and provides  clients the ability to choose to implement GMP manufacturing in-house or with one of Snapdragon Chemistry’s network of GMP manufacturing partners. There is no need to worry about technology transfer.

 

The GMP process covers everything from the starting materials, premises, equipment, and quality systems to the training and personal hygiene of the staff. Detailed written procedures are documented to ensure that the correct procedures are consistently followed at each step in the process.

 

The compliance process begins before the project starts. Everything is validated: a methodology is established through documented evidence for each procedure, process, equipment, material, activity, and system. Documented measures are taken to validate the production process to ensure quality and safety. This is a seamless process to our customers. We’ve got you covered.