Snapdragon Chemistry leverages its scientific expertise, proprietary continuous flow technology & automated experimentation platforms to accelerate product development.
Snapdragon Chemistry is a leader in developing continuous flow chemistry solutions for the discovery and production of active pharmaceutical ingredient, intermediates, and materials. Since our founding in 2014, we have focused on the development of practical continuous manufacturing solutions for challenging chemical transformations to enable us to discover, develop and implement scalable synthetic processes for our clients.
Our clients include companies discovering and manufacturing pharmaceuticals, animal care products, materials, and other fine chemicals. These clients are seeking innovative, productive and robust solutions to their discovery and manufacturing needs.
Our approach leverages flow-based retrosynthetic analysis and reaction design. We apply fundamental chemical and engineering principles to design in robustness. We employ an array of in-line and at-line PAT technologies for real time monitoring and control. Process demonstration on multi-gram scale is then followed by pilot scale production with our local manufacturing partner (GMP-capable) or through transfer to the client’s network.
To help our clients harness the significant, lasting advantages of continuous flow technology and autonomous reaction platforms to transform their entire discovery, development & manufacturing value chain.
We believe that developing and implementing autonomous reaction development and optimization platforms based upon continuous flow technology will transform chemical process research and development. These tools will impact discovery and manufacturing paradigms across a variety of industries where organic chemistry is central to product realization. Those that can harness flow technology while applying artificial intelligence and machine learning early will have a decisive, lasting advantage over competitors as the technology enables important productivity, efficiency and speed enhancements.
Our primary focus is to support you in overcoming challenges and successfully achieving your objectives. Providing excellent client service and building a lasting partnership with you underpin everything that we do.
SCIENTIFIC EXCELLENCE AND INNOVATION
We believe that scientific innovation is paramount to delivering best-in-class products and services to our clients. We have created an unparalleled network of academic and industry experts that enables our offerings to remain at the forefront of continuous flow technology.
Our employees are not only the best and brightest scientists but also exceptional people. As our most valuable resource, they provide outstanding services and products. Our entrepreneurial culture and emphasis on scientific distinction attracts like-minded scientists who seek to tackle and resolve the most complex and challenging problems.
OUR SCIENTIFIC ADVISORY BOARD
Timothy F. Jamison, Ph.D
Co-Founder and Scientific Advisor
A world-renowned expert in flow chemistry, methodology development, and organic synthesis, Tim Jamison founded Snapdragon Chemistry with a vision to enhance the entire drug discovery >> development >> manufacturing value chain through flow chemistry. With a career spanning over 15 years as a Professor of Chemistry at the Massachusetts Institute of Technology (MIT), including as Department Head of Chemistry, Tim has advanced the organic chemistry field with over 125 academic publications. Tim is also a key scientific leader in the Novartis-MIT Center for Continuous Manufacturing, where he makes fundamental contributions to the initiative with his expertise in flow chemistry. In addition, he has worked with numerous pharmaceutical companies to solve some of their most difficult chemistry challenges that arise in their drug discovery/development efforts.
Aaron B. Beeler, PhD
Co-Founder and Synthetic Technologies Advisor
Aaron Beeler is an Assistant Professor of Chemistry at Boston University and, prior to that, was Associate Director of the Center for Chemical Methodology and Library Development at Boston University. Aaron has authored 31 publications and has 2 patents. In addition, he has made fundamental contributions to flow chemistry and medicinal chemistry and shares in the same vision as Tim of transforming drug discovery/development through flow chemistry. Aaron’s research has contributed considerably to the development of unique reactor designs in flow chemistry and has enabled, among other things, photochemistry to create unique building blocks that greatly expand the medicinal chemists’ toolkit for discovering more effective medicines.
Christopher J. Welch, PhD
Christopher J. Welch is Chief Scientific Officer for Welch Innovation, LLC, an independent research and consulting firm located in Cranbury, NJ USA. Dr. Welch has worked in a variety of fields within the chemical industry, including discovery synthesis of agrochemicals (Velsicol-Sandoz), development of reagents for improved immunodiagnostic assays (Abbott Laboratories), development and commercialization of chromatographic stationary phases, reagents and enantioselective catalysts within a small chemical business environment (Regis Technologies) and the invention and application of new purification, analysis and high throughput experimentation technologies for pharmaceutical process research (Merck & Co.). Dr. Welch has authored more than 250 scientific publications and patents. He is co-founder of the journal, Enantiomer, a member of the editorial advisory board for the journals, Chirality, Journal of the Korean Chemical Society, Chemistry World and ACS Central Science. He has received honors and awards including the NJCG Award for Excellence in Chromatography, the PACS Activated Carbon Hall of Fame award, Merck Research Laboratories Presidents Award for Environmental Achievement, Microsoft Life Science Innovation Award, Fellow of the American Chemical Society, Fellow of the American Association for the Advancement of Science, the Chirality Medal, the University of Nebraska Chemistry Industrial Award and the EAS Award for Outstanding Achievement in Separation Science.
Stephen L. Buchwald, PhD
Steve Buchwald is the Camille Dreyfus Professor of Chemistry at the Massachusetts Institute of Technology (MIT) and is an expert in new chemical reaction methodology/development. His academic career has spanned over thirty years, during which he has co-authored over 420 academic publications and has 44 issued patents. His numerous honors and awards include the 2013 Arthur C. Cope Award from the American Chemical Society, the 2014 Linus Pauling Medal Award, and the 2014 BBVA Foundation Frontiers of Knowledge Award in Basic Sciences (awarded in 2015). He was elected as a fellow of the American Academy of Arts and Sciences in 2000 and as a member of the National Academy of Sciences in 2008. Professor Buchwald also serves as a scientific consultant to many companies and is an associate editor of Advanced Synthesis & Catalysis.
Andrea Adamo, PhD
Andrea Adamo is the CEO of Zaiput Flow Technologies — a leading continuous flow equipment design/manufacturing firm — and an entrepreneur with extensive experience in the development of innovative engineering solutions. Dr. Adamo holds a Master of Science in Engineering from the University of Palermo, Italy and a Ph.D. in Fluid Mechanics from the University Federico II of Naples, Italy, in addition to a Master of Science from the Massachusetts Institute of Technology (MIT). He was also awarded a Fulbright Scholarship. After completing his graduate studies, Dr. Adamo joined the laboratory of Professor Klavs Jensen, in MIT’s Chemical Engineering Department. He worked in the Jensen Group first as a post-doctoral associate and then as a research associate. In these positions, Dr. Adamo gained extensive experience in the design and manufacturing of innovative microfluidic and millifluidic systems.
Our leadership team and advisory board are comprised of preeminent scientists and experienced thought leaders who are passionate about helping you drive results, unlock potential, and maximize value by taking full advantage of continuous flow technology. Collectively, our team has advised many leading pharmaceutical companies and chemical manufacturers on their most important chemistry challenges.
Matthew M. Bio, PhD
President and Chief Executive Officer
Matthew Bio brings substantial experience in process development to Snapdragon Chemistry and is driven by a passion for developing new technologies in organic synthesis; enabling safer, more efficient processes; and providing access to new chemical architectures. Matthew earned his Ph.D. in Chemistry from Columbia University and went on to work as a process development chemist at Merck Research Laboratories. In 2006, Matthew moved to Amgen, where he was promoted to Director of Process Development and led the development of both batch and continuous processes for clinical candidates. Throughout his career, Matthew has been involved in the development of more than 50 clinical candidates and the launch of three new drugs to the market, and is author or inventor on numerous regulatory filings and more than 30 peer-reviewed publications and patents.
Eric Fang, Ph.D.
Chief Scientific Officer
Eric Fang drives a rigorous and fundamental approach to chemical process development at Snapdragon Chemistry. As Chief Scientific Office Eric oversees all projects and guides solution delivery by building deep understanding of all projects through kinetic and thermodynamic analyses. Eric completed his Ph.D. in Organic Chemistry at the University of Toronto under the direction of Professor Mark Lautens. Subsequently, Eric worked with Professor Eric Jacobsen as an NSERC postdoctoral fellow at Harvard University where he focused on asymmetric catalysis and natural product synthesis. He began his industrial career at Amgen in Small Molecule Process and Product Development. He quickly rose in levels of responsibility while developing elegant synthetic routes and bring new process technologies to many complex molecules in Amgen's pipeline. Eric is passionate about the tremendous power and opportunity Snapdragon's core technology brings to the development and application of continuous synthetic routes to complex molecules.
Snapdragon Chemistry’s main focus is to deliver value to our clients. Thus, we have partnered with trusted, cutting-edge organizations that complement our skill sets and services, to provide the best solutions to our clients.
Johnson Matthey is a global leader in science that enables cleaner air, improved health and more efficient use of natural resources. JM has an extensive offering in clinical to commercial API development and manufacturing, which includes considerable quality systems infrastructure.
Our collaboration with JM creates a complete and powerful end-to-end offering that can provide the full scope of process development and manufacturing services, from flow chemistry route conception to cGMP bulk production. Snapdragon Chemistry and JM have co-located facilities in the Boston area, allowing joint Snapdragon Chemistry and JM teams to interact closely to both develop flow chemistry processes and scale those processes through to manufacturing. This will allow clients to take full advantage of continuous manufacturing technology throughout the drug development life cycle.
Zaiput Flow Technologies
Zaiput Flow Technologies is dedicated to bringing innovative tools for continuous flow to the market. Zaiput specializes in modular liquid-liquid separators and back pressure regulators for a variety of flow rates and with robust designs for harsh chemistries.
Through our partnership with Zaiput Flow Technologies, we will bring the most innovative and effective continuous flow technology to our clients. Zaiput and Snapdragon Chemistry are co-located in the Boston area, enabling us to collaborate efficiently to build cutting-edge reactor systems for continuous flow synthesis.
Paraza Pharma, Inc
Paraza Pharma, Inc. is an innovative company with an aim to improve significantly the efficiency of the drug discovery process from lead identification through lead optimization to development candidates.
Paraza complements Snapdragon Chemistry’s expertise in drug discovery and enables us to provide more holistic, innovative solutions to our clients in the discovery and early development space. Our combined insights, experience, and workforce help power an integrated solution that can completely transform productivity in discovery.