Snapdragon Chemistry and Johnson Matthey Collaborate to Bring Effective Continuous Manufacturing Solutions to Pharma and Biotech

Snapdragon Chemistry Inc., a leader in flow chemistry process design and technology development, and Johnson Matthey (LSE: JMAT), a global leader in science that enables cleaner air, improved health and more efficient use of natural resources, are pleased to announce that they have entered in to a collaborative agreement to provide integrated continuous manufacturing services – from development to full-scale GMP manufacturing.

Continuous flow chemistry can transform pharmaceutical manufacturing processes by reducing the number of synthetic steps while increasing yield, enhancing purity and providing more effective quality controls, resulting in reduced capital expenditure and increased speed to market. Yet the pharmaceutical and biotech industries have yet to fully adopt this transformational technology. The collaboration between Johnson Matthey (JM) and Snapdragon Chemistry will address this by creating a complete and powerful end-to-end offering that can provide the full scope of process development and manufacturing services, from flow chemistry route conception to cGMP bulk production.

The agreement combines Snapdragon Chemistry’s cutting-edge flow chemistry design, development and characterisation capabilities with JM’s offering in clinical to commercial API development and manufacturing, which includes considerable quality systems infrastructure, together with JM’s expertise in continuous manufacturing processes.

“Snapdragon has outstanding skills, capabilities and people for the development of continuous flow chemistry,” commented Robert MacLeod, Chief Executive of JM. “With this collaboration we will be able to unlock significant value for customers through the rapid development of more efficient, sustainable and robust manufacturing processes.”

“We are delighted to be partnering with JM,” said Matthew Bio, President and CEO Snapdragon Chemistry. “They are a leading provider of API development and manufacturing services and we share similar passions for innovation and delivery of quality science, engineering and materials to our clients.”

The two companies have co-located facilities in the Boston area, allowing joint Snapdragon Chemistry and JM teams to interact closely to both develop flow chemistry processes and scale those processes through to manufacturing. This will allow clients to take full advantage of continuous manufacturing technology throughout the drug development life cycle.

About Snapdragon Chemistry, Inc.
Snapdragon Chemistry is a privately held company based in Cambridge, MA. Snapdragon was founded in 2014 as a contract research organization with the mission to deliver advanced continuous manufacturing technology solutions for innovators in the pharmaceutical, fine chemical and materials industries. Snapdragon is investing in the development of new technologies to automate flow chemical process development to deliver clients dramatically reduced timelines, enable rapid scale-up of flow processes and ensure consistent product quality across the continuum from milligrams to kilograms.

About Johnson Matthey
Johnson Matthey is a global leader in science that enables a cleaner and healthier world. With over 200-years of sustained commitment to innovation and technological breakthroughs that improve the function, performance and safety of our customer’s products. Our science has a global impact in areas such as low emission transport, pharmaceuticals, chemical processing and making the most efficient use of the planet’s natural resources. Today more than 13,000 Johnson Matthey professionals collaborate with our network of customers and partners to make a real difference to the world around us. For more information, visit matthey.comInspiring science, enhancing life

 

Snapdragon Chemistry receives MassRamp Grant for Automating Chemical Development

Snapdragon has received a $200,000 grant from the Massachusetts Life Sciences Center (MLSC) to support our research into the use of flow chemistry, online analysis, algorithms and IoT to automate the development chemical synthesis. MLSC is awarding $1.4 million to seven life sciences companies through the new Massachusetts Ramp-Up Program (MassRamp). MassRamp is a new program that will provide grant funding to promising early-stage life sciences companies. The awards are intended to help bridge the funding gaps associated with the long R&D cycle, and the high cost of translating research into commercially viable products.  The MassRamp grant to Snapdragon will accelerate our efforts to digitize chemistry.

Matt Bio discusses flow reactor systems coupled to computer algorithms to auto-optimize chemical process development at Launch

Snapdragon Chemistry's CEO Matt Bio recently participated in a Circular Innovation Summit facilitated by the LAUNCH organization.  LAUNCH  is a network-centered innovation platform that connects innovators to other innovators and to mentors to help realize technologies and approaches that address sustainability challenges.  In 2016 LAUNCH, founded by NASA, the U.S. Agency for International Development, the U.S. Department of State and NIKE, Inc., solicited approaches that would help accelerate a shift towards more sustainable molecules, mixtures, and materials.  Snapdragon Chemistry's proposal for a system coupling flow-chemistry development to computer-aided optimization was one of only five innovations selected by LAUNCH for participation in their program (story available here). 

The innovation summit brought together leading researchers, entrepreneurs, investors, and business executives at NIKE’s world headquarters in Portland, Oregon.  Matt discussed the system under development by Snapdragon Chemistry during the summit.

Dr. Eric Fang Promoted to Chief Scientific Officer

Dr. Eric Fang, Snapdragon Chemistry CSO

We are thrilled to announce the promotion of Dr. Eric Fang to the position of Chief Scientific Officer of Snapdragon Chemistry.  Eric joined Snapdragon Chemistry as Director of Chemistry in November of 2015 from Amgen.  During Eric’s time at Amgen he continued to push process development for scalable and safe syntheses of complex small molecules towards greater elegance and efficiency.  This continuing innovation naturally pushed him towards the application of flow chemistry.  As Eric sought to be more on the forefront of flow chemistry development and utilization, Snapdragon Chemistry recruited him into the role of Director of Chemistry.  In this role he immediately began leveraging the intrinsic capabilities of Snapdragon Chemistry and the vision and know-how of its founders to deliver value to Snapdragon Chemistry’s clients.  Eric has helped push continuous innovation at Snapdragon Chemistry in delivering robust flow chemistry processes as well as in the development of enabling tools and devices that have added to Snapdragon Chemistry’s capabilities.  In recognition of this work and the vision and leadership Eric brings to our clients and our internal research and development efforts, the Board of Directors of Snapdragon Chemistry approved the promotion of Eric to this critical role.  As Chief Scientific officer Eric will continue to direct chemistry development for Snapdragon Chemistry’s client projects and internal research and development efforts.

NSF Awards Snapdragon Chemistry Phase I SBIR

NSF Heading.jpg

Snapdragon Chemistry is pleased to announce we have been awarded a Phase I Small Business Innovation Research (SBIR) grant from the National Science Foundation (NSF) for the development of an electrochemical method for the manufacture of chemicals of interest to pharmaceutical, agricultural and fine chemical producers (Award #1645765).  This SBIR Phase I project is aimed at the development of an electrochemically-mediated reaction using flow chemistry as practical, safe and sustainable means of replacing hazardous and environmentally damaging catalysts and reagents in the manufacture of high-value chemicals and materials.


Matthew Bio (Snapdragon Chemistry CEO) notes, “We are very happy and thankful for the recognition by the NSF of both the potential of direct electrochemical methods for synthesis and the need for the development of new methods and devices for flow chemistry.  Flow is clearly an enabling technology for electrochemistry and Snapdragon’s expertise makes us uniquely positioned to develop practical electrochemical flow processes.”  Co-founder Professor Tim Jamison noted “We appreciate the support of the SBIR program and are excited by the opportunity to expand Snapdragon’s research in flow electrochemistry.”


The NSF SBIR program is highly competitive.  The grants available through this program help initiate and facilitate small businesses in the U.S. to undertake research and development of highly speculative technologies that have significant commercial potential if successful.  This selective program helps small technology businesses like Snapdragon Chemistry realize innovation goals and engenders entrepreneurship facilitating the delivery of high-tech products and growing the companies of tomorrow.

 

Snapdragon Chemistry Adds Corning Low-flow Reactor

Corning's Low-flow Reactor

Corning's Low-flow Reactor

Snapdragon Chemistry, Inc. continues to add capabilities to enable cutting-edge flow chemistry development by adding Corning’s Advanced Flow™ (AFR) technology to its laboratory.  This acquisition is an important addition to Snapdragon Chemistry’s tool box which will help us achieve the mission of discovering, developing and transferring new or improved processes for fine-chemical and pharmaceutical production for our customers.

Corning’s versatile and powerful Low-Flow reactor is being utilized in the Snapdragon facility to enable chemistry development and identify appropriate and efficient synthetic routes that can easily and seamlessly be transferred to industrial production.  The installation of the reactor in Snapdragon’s laboratory provides Corning’s customers in the Cambridge, MA area with ready access to continuous-flow demonstrations and experimental trials at a small scale for early stage processes as well as guidance with developing new flow chemistry processes.  While Corning’s AFR business has been around for more than 10 years, Allessandra Vizza, regional commercial manager, EMEA, Americas, Corning AFR Technology observed, “The utilization of continuous flow solutions is still a new concept for many current and potential customers in North America.  Providing our customers with Corning’s engineering and equipment capabilities coupled with Snapdragon’s chemistry expertise is a win for everyone.”

“We are very pleased to add Snapdragon to our global network of collaborators,” said Dr. Yi Jiang, global business director for Corning Reactor Technologies.  “They have extensive chemistry expertise in pharmaceutical, fine, and specialty chemical industries and employ chemists who are skilled at applying various synthetic methods which are key parameters for the appropriate utilization of AFR reactors.”  See Corning's announcement here.

Snapdragon Chemistry

Snapdragon is very excited to be working with Corning and their AFR technology. “The extensive engineering and design consideration that went in to developing the Corning family of reactors ensures that processes we develop in the Low-Flow reactor can be quickly scaled to commercial production,” said Matthew Bio, Snapdragon President and Chief Executive Officer.  “The superior mixing and heat transfer properties of Corning’s reactors routinely provide excellent results even with the most challenging reactions.  In addition, the modular design of the Corning system provides a flexible and easy-to-use platform for flow chemistry development.”

Snapdragon Chemistry and Apeiron Synthesis Explore Opportunities to Collaborate

Snapdragon Chemistry and Apeiron Synthesis have been meeting over the summer to gain a better understanding of each companies’ strengths and areas of mutual interest.  The outcome of these discussions was a recognition of complementary capabilities and a shared passion for transforming chemical development and production.  To build on these preliminary discussions, Snapdragon Chemistry and Apeiron Synthesis recently agreed to explore opportunities to collaborate.  This partnership will couple Apeiron Synthesis’s excellence in metathesis catalysis with Snapdragon Chemistry’s full lifecycle approach to designing continuous processes to deliver low cost and just-in-time production of fine chemicals.

An announcement of this partnership and comments from both companies’ CEO’s is also available on Apeiron Synthesis’s website.

Snapdragon Co-founder Tim Jamison talks Pharmacy on Demand with NPR

The Pharmacy on Demand (PoD) technology continues to attract national attention in the popular press.  This week Tim Jamison, Snapdragon Chemistry co-founder, was interviewed about the PoD technology on National Public Radio's All Things Considered.  Tim shared his vision for how continuous manufacturing is changing the way pharmaceuticals and fine chemicals are manufactured.  Hear the full interview on PoD on NPR's website here: http://www.npr.org/sections/health-shots/2016/05/23/478576727/inventing-a-machine-that-spits-out-pills-a-whole-new-way

Snapdragon Chemistry Announces Expansion to New Labs in Cambridge, Added Technical Services, and Election of Matt Bio as Chief Executive Officer

Snapdragon Chemistry is pleased to make several significant announcements.  First, Snapdragon has moved to new lab facilities at 85 Bolton Street in Cambridge, Massachusetts.   Snapdragon’s corporate partner, Zaiput Flow Technologies, has also moved to the 85 Bolton Street site.  This co-location will enhance the collaboration of these strategic partners and accelerate the development of advanced continuous chemical manufacturing technologies and solutions.

Snapdragon also announces completion of an investment round that enables both the significant expansion of its capabilities and technologies and the recruitment of additional top scientists in order to keep pace with the high demand for Snapdragon’s services.  Snapdragon is expanding its reaction profiling and analytical capabilities to include additional in-line process analytical technologies (PAT), including real-time and automated feedback control of process parameters.  Snapdragon is also expanding its computational modeling capabilities, using reaction-profiling data in order to deliver “right-first-time” reactor design.

As part of the expansion, Snapdragon has hired Dr. Eric Fang as Director of Chemistry and added both PhD and BS level chemists.  Snapdragon also plans to hire additional scientists and engineers in the near future.

Finally, in recognition of his contributions to the expansion of the company and the successful fundraising round, Snapdragon is pleased to announce the election of Dr. Matthew Bio to President and CEO, succeeding the current President/CEO and Co-Founder Tim Jamison.  Jamison will continue as Chairman and as scientific and technical advisor to Snapdragon.  Co-founder Aaron Beeler will also continue to serve on the board of directors and as scientific and technical advisor.

Matthew Bio, Ph.D., joins Snapdragon Chemistry as its Chief Scientific Officer

Snapdragon Chemistry is proud to announce that Matthew Bio, Ph.D., will join as its Chief Scientific Officer. Dr. Bio brings a wealth of leadership and expertise in cutting-edge chemical synthesis development to Snapdragon Chemistry during an exciting point in Snapdragon Chemistry's growth; he shares Snapdragon's passion for helping companies harness continuous flow synthesis to drive unparalleled value in their operations.

Dr. Bio comes to Snapdragon Chemistry from Amgen Inc., where he most recently served as Director of Process Development and Head of the Synthetic and Hybrid Technologies group. At Amgen, he was responsible for setting the scientific direction of process development for synthetic drug candidates and for leading development of the first continuous process at Amgen.

Aaron Beeler, our co-founder, acting CSO, and Assistant Professor of Chemistry at Boston University, will continue to remain actively engaged as the company’s Synthetic Technologies Advisor.