Snapdragon Chemistry's Contributions Recognized in C&EN's Research of the Year Article

Each year Chemical & Engineering News looks back in their "Research of the Year" article highlighting some notable advances in research for the year coming to a close .  This year two of our collaborations were discussed in the section of the article:  Flow Chemistry Advanced in Industry.  The first was our collaboration with Pfizer in which we developed and demonstrated a scalable route employing allenyllithium to prepare a chiral homopropargyl amino alcohol.  This exciting work blazed a trail for us to apply our expertise in developing and scaling continuous and robust transmetallation reactions which we did for many clients in 2017.

C&EN also noted the collaboration we announced with Johnson Matthey Pharma Services to develop and scale continuous processes.  As 2018 begins we are excited to be on the precipice of executing kilogram quantity production runs of chemistry developed at our labs within Johnson Matthey's outstanding facilities in conjunction with their superb technical and facilities staff.

Snapdragon will participate in the Inaugural ‘Advancing Drug Development Forum - Making the Impossible Possible'

Snapdragon Chemistry will participate in the inaugural 'Advancing Drug Development Forum - Making the Impossible Possible'.  The scope of this event will be to explore new solutions, promising technology breakthroughs and how industry introduces and incorporates improved approaches in drug development.  The program includes an opening and closing keynote and a couple provocative and focused panel discussions demonstrating some of the approaches in improving ways to address complex formulation development and manufacturing methods of small molecule compounds.

Matt will be participating as a panelist for one of the discussions.  We are excited to explore in this venue how new approaches and advanced manufacturing methods can continue to enable and speed pharmaceutical development.

Snapdragon Chemistry Celebrates the Third Anniversary of Our Founding

Snapdragon Chemistry

Snapdragon Chemistry

Snapdragon Chemistry is proud and happy to celebrate the third anniversary of our founding.  Over these three years we have been fortunate to work closely with more than twenty clients hailing from bulk chemical, agrichemical and pharmaceutical sectors.  We are grateful to each one of our clients and especially thankful to the many who have endorsed our partnership by returning across these years with multiple projects.  Our clients have brought us abundant opportunities to deliver flow chemistry processes that are more productive, more inherently safe, and more environmentally responsible.  They have embraced new technologies ranging from scalable photochemistry to electrochemistry to ultra-fast reaction skids.  We appreciate the support they have provided and the vision they have shown as we have grown our business.

This growth has included adding additional scientists and engineers; expanding our laboratory, administrative and workshop spaces; and enhancing our capabilities and development options.  Growth has also come in the form of our partnership with Johnson Matthey that now allows us to provide a full end-to-end offering for pharmaceutical flow chemistry from route conception to development to cGMP manufacture.  It also includes our joining of CMAC to help lead the next developments in flow chemistry manufacture.

Over these three years we have benefited greatly from the insightful and tireless guidance of our scientific advisory board.  These science and technology leaders have been our ardent and vocal proponents as they have challenged us to bring the best innovations forward.  As we look forward to the future, we are excited by the accelerating interest and adoption of flow chemistry across the discovery, development, and manufacturing life cycle.  We look forward to continuing to work with our current clients, adding new clients, and being at the forefront of innovation in this exciting field!

Snapdragon Chemistry Joins the Center for Continuous Manufacturing and Crystallization (CMAC) as a Tier 2 Industry Partner

Snapdragon Chemistry Inc., a leader in flow chemistry process design and technology development, is pleased to announce their joining the Center for Continuous Manufacturing and Crystallization (CMAC) as a Tier 2 industry partner.  Snapdragon will provide its expertise and access to its technologies to the center to help further CMAC’s research goals.

CMAC is a world-class national center delivering innovative ways to translate new molecules into high-value products.  CMAC, led by the University of Strathclyde, has teams working in concert across seven UK universities.  The center’s research is supported in part by the Engineering and Physical Sciences Research Council (EPSRC) and is informed by extensive engagement with national and global industry, end-users, technology providers, international academic programs and regulatory agencies.  Additional support is realized through industrial partnerships including Tier 1 industry partners - GSK, AstraZeneca, Novartis, Bayer, Lilly, and Takeda.

As a Tier 2 partner Snapdragon Chemistry is proud to join and partner with the 17 Tier 2 technology companies, the 7 Tier 1 pharmaceutical companies and university research groups that share CMAC’s goal of revolutionizing how pharmaceuticals and high value products are made.

“We are delighted to join CMAC as a Tier 2 partner,” said Snapdragon Chemistry’s CEO Matthew Bio.  “Academic/industrial partnerships like CMAC have demonstrated power in accelerating innovation and adoption in many technically challenging areas.  Snapdragon Chemistry shares CMAC’s passion for creation and adoption of continuous manufacturing technologies which will undoubtedly lead to processes that deliver products in higher quality, with lower cost and improved sustainability.”

Snapdragon Chemistry and Johnson Matthey Collaborate to Bring Effective Continuous Manufacturing Solutions to Pharma and Biotech

Snapdragon Chemistry Inc., a leader in flow chemistry process design and technology development, and Johnson Matthey (LSE: JMAT), a global leader in science that enables cleaner air, improved health and more efficient use of natural resources, are pleased to announce that they have entered in to a collaborative agreement to provide integrated continuous manufacturing services – from development to full-scale GMP manufacturing.

Continuous flow chemistry can transform pharmaceutical manufacturing processes by reducing the number of synthetic steps while increasing yield, enhancing purity and providing more effective quality controls, resulting in reduced capital expenditure and increased speed to market. Yet the pharmaceutical and biotech industries have yet to fully adopt this transformational technology. The collaboration between Johnson Matthey (JM) and Snapdragon Chemistry will address this by creating a complete and powerful end-to-end offering that can provide the full scope of process development and manufacturing services, from flow chemistry route conception to cGMP bulk production.

The agreement combines Snapdragon Chemistry’s cutting-edge flow chemistry design, development and characterisation capabilities with JM’s offering in clinical to commercial API development and manufacturing, which includes considerable quality systems infrastructure, together with JM’s expertise in continuous manufacturing processes.

“Snapdragon has outstanding skills, capabilities and people for the development of continuous flow chemistry,” commented Robert MacLeod, Chief Executive of JM. “With this collaboration we will be able to unlock significant value for customers through the rapid development of more efficient, sustainable and robust manufacturing processes.”

“We are delighted to be partnering with JM,” said Matthew Bio, President and CEO Snapdragon Chemistry. “They are a leading provider of API development and manufacturing services and we share similar passions for innovation and delivery of quality science, engineering and materials to our clients.”

The two companies have co-located facilities in the Boston area, allowing joint Snapdragon Chemistry and JM teams to interact closely to both develop flow chemistry processes and scale those processes through to manufacturing. This will allow clients to take full advantage of continuous manufacturing technology throughout the drug development life cycle.

About Snapdragon Chemistry, Inc.
Snapdragon Chemistry is a privately held company based in Cambridge, MA. Snapdragon was founded in 2014 as a contract research organization with the mission to deliver advanced continuous manufacturing technology solutions for innovators in the pharmaceutical, fine chemical and materials industries. Snapdragon is investing in the development of new technologies to automate flow chemical process development to deliver clients dramatically reduced timelines, enable rapid scale-up of flow processes and ensure consistent product quality across the continuum from milligrams to kilograms.

About Johnson Matthey
Johnson Matthey is a global leader in science that enables a cleaner and healthier world. With over 200-years of sustained commitment to innovation and technological breakthroughs that improve the function, performance and safety of our customer’s products. Our science has a global impact in areas such as low emission transport, pharmaceuticals, chemical processing and making the most efficient use of the planet’s natural resources. Today more than 13,000 Johnson Matthey professionals collaborate with our network of customers and partners to make a real difference to the world around us. For more information, visit matthey.comInspiring science, enhancing life


Snapdragon Chemistry receives MassRamp Grant for Automating Chemical Development

Snapdragon has received a $200,000 grant from the Massachusetts Life Sciences Center (MLSC) to support our research into the use of flow chemistry, online analysis, algorithms and IoT to automate the development chemical synthesis. MLSC is awarding $1.4 million to seven life sciences companies through the new Massachusetts Ramp-Up Program (MassRamp). MassRamp is a new program that will provide grant funding to promising early-stage life sciences companies. The awards are intended to help bridge the funding gaps associated with the long R&D cycle, and the high cost of translating research into commercially viable products.  The MassRamp grant to Snapdragon will accelerate our efforts to digitize chemistry.

Matt Bio discusses flow reactor systems coupled to computer algorithms to auto-optimize chemical process development at Launch

Snapdragon Chemistry's CEO Matt Bio recently participated in a Circular Innovation Summit facilitated by the LAUNCH organization.  LAUNCH  is a network-centered innovation platform that connects innovators to other innovators and to mentors to help realize technologies and approaches that address sustainability challenges.  In 2016 LAUNCH, founded by NASA, the U.S. Agency for International Development, the U.S. Department of State and NIKE, Inc., solicited approaches that would help accelerate a shift towards more sustainable molecules, mixtures, and materials.  Snapdragon Chemistry's proposal for a system coupling flow-chemistry development to computer-aided optimization was one of only five innovations selected by LAUNCH for participation in their program (story available here). 

The innovation summit brought together leading researchers, entrepreneurs, investors, and business executives at NIKE’s world headquarters in Portland, Oregon.  Matt discussed the system under development by Snapdragon Chemistry during the summit.

Dr. Eric Fang Promoted to Chief Scientific Officer

Dr. Eric Fang, Snapdragon Chemistry CSO

We are thrilled to announce the promotion of Dr. Eric Fang to the position of Chief Scientific Officer of Snapdragon Chemistry.  Eric joined Snapdragon Chemistry as Director of Chemistry in November of 2015 from Amgen.  During Eric’s time at Amgen he continued to push process development for scalable and safe syntheses of complex small molecules towards greater elegance and efficiency.  This continuing innovation naturally pushed him towards the application of flow chemistry.  As Eric sought to be more on the forefront of flow chemistry development and utilization, Snapdragon Chemistry recruited him into the role of Director of Chemistry.  In this role he immediately began leveraging the intrinsic capabilities of Snapdragon Chemistry and the vision and know-how of its founders to deliver value to Snapdragon Chemistry’s clients.  Eric has helped push continuous innovation at Snapdragon Chemistry in delivering robust flow chemistry processes as well as in the development of enabling tools and devices that have added to Snapdragon Chemistry’s capabilities.  In recognition of this work and the vision and leadership Eric brings to our clients and our internal research and development efforts, the Board of Directors of Snapdragon Chemistry approved the promotion of Eric to this critical role.  As Chief Scientific officer Eric will continue to direct chemistry development for Snapdragon Chemistry’s client projects and internal research and development efforts.

NSF Awards Snapdragon Chemistry Phase I SBIR

NSF Heading.jpg

Snapdragon Chemistry is pleased to announce we have been awarded a Phase I Small Business Innovation Research (SBIR) grant from the National Science Foundation (NSF) for the development of an electrochemical method for the manufacture of chemicals of interest to pharmaceutical, agricultural and fine chemical producers (Award #1645765).  This SBIR Phase I project is aimed at the development of an electrochemically-mediated reaction using flow chemistry as practical, safe and sustainable means of replacing hazardous and environmentally damaging catalysts and reagents in the manufacture of high-value chemicals and materials.

Matthew Bio (Snapdragon Chemistry CEO) notes, “We are very happy and thankful for the recognition by the NSF of both the potential of direct electrochemical methods for synthesis and the need for the development of new methods and devices for flow chemistry.  Flow is clearly an enabling technology for electrochemistry and Snapdragon’s expertise makes us uniquely positioned to develop practical electrochemical flow processes.”  Co-founder Professor Tim Jamison noted “We appreciate the support of the SBIR program and are excited by the opportunity to expand Snapdragon’s research in flow electrochemistry.”

The NSF SBIR program is highly competitive.  The grants available through this program help initiate and facilitate small businesses in the U.S. to undertake research and development of highly speculative technologies that have significant commercial potential if successful.  This selective program helps small technology businesses like Snapdragon Chemistry realize innovation goals and engenders entrepreneurship facilitating the delivery of high-tech products and growing the companies of tomorrow.


Snapdragon Chemistry Adds Corning Low-flow Reactor

Corning's Low-flow Reactor

Corning's Low-flow Reactor

Snapdragon Chemistry, Inc. continues to add capabilities to enable cutting-edge flow chemistry development by adding Corning’s Advanced Flow™ (AFR) technology to its laboratory.  This acquisition is an important addition to Snapdragon Chemistry’s tool box which will help us achieve the mission of discovering, developing and transferring new or improved processes for fine-chemical and pharmaceutical production for our customers.

Corning’s versatile and powerful Low-Flow reactor is being utilized in the Snapdragon facility to enable chemistry development and identify appropriate and efficient synthetic routes that can easily and seamlessly be transferred to industrial production.  The installation of the reactor in Snapdragon’s laboratory provides Corning’s customers in the Cambridge, MA area with ready access to continuous-flow demonstrations and experimental trials at a small scale for early stage processes as well as guidance with developing new flow chemistry processes.  While Corning’s AFR business has been around for more than 10 years, Allessandra Vizza, regional commercial manager, EMEA, Americas, Corning AFR Technology observed, “The utilization of continuous flow solutions is still a new concept for many current and potential customers in North America.  Providing our customers with Corning’s engineering and equipment capabilities coupled with Snapdragon’s chemistry expertise is a win for everyone.”

“We are very pleased to add Snapdragon to our global network of collaborators,” said Dr. Yi Jiang, global business director for Corning Reactor Technologies.  “They have extensive chemistry expertise in pharmaceutical, fine, and specialty chemical industries and employ chemists who are skilled at applying various synthetic methods which are key parameters for the appropriate utilization of AFR reactors.”  See Corning's announcement here.

Snapdragon Chemistry

Snapdragon is very excited to be working with Corning and their AFR technology. “The extensive engineering and design consideration that went in to developing the Corning family of reactors ensures that processes we develop in the Low-Flow reactor can be quickly scaled to commercial production,” said Matthew Bio, Snapdragon President and Chief Executive Officer.  “The superior mixing and heat transfer properties of Corning’s reactors routinely provide excellent results even with the most challenging reactions.  In addition, the modular design of the Corning system provides a flexible and easy-to-use platform for flow chemistry development.”